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#plasticity

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Meuthen IDEA LAB

New📜preprint from the @idealab out today! We propose that epigenetic mechanisms mediate the realization of individualized niches. Furthermore, we suggest that the realization of individualized niches can contribute to both the emergence and maintenance of epigenetic variation. This opinion piece is the result of a large collaboration within the DFG-funded NC³ collaborative research center - A Novel Synthesis of Individualisation across Behaviour, Ecology and Evolution: Niche Choice, Niche Conformance, Niche Construction uni-bielefeld.de/fakultaeten/b ). It is now available on EcoEvoRxiv: doi.org/10.32942/X2Z34V #ecology #evolution #plasticity #epigenetics #individualisation
#AcademicMastodon @academicchatter

www.uni-bielefeld.deSFB-TRR 212 - Bielefeld University
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Giuseppe Bilotta

I'll take the opportunity to open a small parenthesis on what #rheology aka “the science of the flow”, is: the term, which can be used both for fluids and (some classes of) deformable solids describes the relationship between stress and strain in a continumm.

To wit, for something to flow (or deform), there must be a force applied. The relation between this force and how much (and how quickly) the continuum deforms is what rheology is about.

Rheology deals with two main classes of behavior: #plasticity and #viscosity.

Plastic behavior refers to (permanent) deformations whose magnitude depends on the applied force: smaller forces result in smaller deformations, larger forces in larger deformations. This is typical of solids.

Viscous behavior refers to deformations whose rate depends on the applied force: in this sense deformations can be “infinite” (the distance between two given points can grow arbitrarily), and as long as the force is applied the deformation will grow. #Viscosity determines how strongly the continuum (typically a fluid) resits to the deformation, and thus how quickly (or slowly) it deforms.

And of course you can have hybrid behaviors (viscoplastic, viscoelastic, viscoplastoelastic).

5/

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The vOICe vision BCI 🧠🇪🇺

Psilocybin as a treatment for repetitive mild head injury: Evidence from neuroradiology and molecular biology www.biorxiv.org/content/10.1... "#psilocybin can reduce vasogenic edema, restore normal vascular reactivity and functional connectivity"; #neuroplasticity, #brain #plasticity, #neuroscience

biorxiv.org/content/10.110...

bioRxiv · Psilocybin as a Treatment for Repetitive Mild Head Injury: Evidence from Neuroradiology and Molecular BiologyRepetitive mild head injuries incurred while playing organized sports, during car accidents and falls, or in active military service are a major health problem. These head injuries induce cognitive, motor, and behavioral deficits that can last for months and even years with an increased risk of dementia, Parkinson's disease, and chronic traumatic encephalopathy. There is no approved medical treatment for these types of head injuries. To this end, we tested the healing effects of the psychedelic psilocybin, as it is known to reduce neuroinflammation and enhance neuroplasticity. Using a model of mild repetitive head injury in adult female rats, we provide unprecedented data that psilocybin can reduce vasogenic edema, restore normal vascular reactivity and functional connectivity, reduce phosphorylated tau buildup, enhance levels of brain-derived neurotrophic factor and its receptor TrkB, and modulate lipid signaling molecules. ### Competing Interest Statement C.F.F. and P.P.K. have a partnership interest in Ekam Imaging Inc., a company that develops RF electronics and 3D MRI atlases for animal research. None of the other authors have a conflict of interest.
Public
The vOICe vision BCI 🧠🇪🇺

Psilocybin as a treatment for repetitive mild head injury: Evidence from neuroradiology and molecular biology biorxiv.org/content/10.1101/20 "#psilocybin can reduce vasogenic edema, restore normal vascular reactivity and #functional #connectivity"; #neuroplasticity, #brain #plasticity, #neuroscience

bioRxiv · Psilocybin as a Treatment for Repetitive Mild Head Injury: Evidence from Neuroradiology and Molecular BiologyRepetitive mild head injuries incurred while playing organized sports, during car accidents and falls, or in active military service are a major health problem. These head injuries induce cognitive, motor, and behavioral deficits that can last for months and even years with an increased risk of dementia, Parkinson's disease, and chronic traumatic encephalopathy. There is no approved medical treatment for these types of head injuries. To this end, we tested the healing effects of the psychedelic psilocybin, as it is known to reduce neuroinflammation and enhance neuroplasticity. Using a model of mild repetitive head injury in adult female rats, we provide unprecedented data that psilocybin can reduce vasogenic edema, restore normal vascular reactivity and functional connectivity, reduce phosphorylated tau buildup, enhance levels of brain-derived neurotrophic factor and its receptor TrkB, and modulate lipid signaling molecules. ### Competing Interest Statement C.F.F. and P.P.K. have a partnership interest in Ekam Imaging Inc., a company that develops RF electronics and 3D MRI atlases for animal research. None of the other authors have a conflict of interest.
Public
The vOICe vision BCI 🧠🇪🇺

#Plasticity of visual looming response reveals a dissociation of innate and learned components (in mice) biorxiv.org/content/10.1101/20 #EMDR for mice? #neuroscience

"Here, we demonstrate that innate looming stimulus responses, an innate predator-evasion behaviour, can be robustly extinguished via repeated unreinforced presentation over several days."

bioRxiv · Plasticity of visual looming response reveals a dissociation of innate and learned componentsAnimals rely on both innate and learned behaviour to respond optimally to their environment. However, little is known about how the brain may reconcile the ability to produce hardwired responses essential to survival while still allowing for adaptive flexibility. Here, we demonstrate that innate looming stimulus responses, an innate predator-evasion behaviour, can be robustly extinguished via repeated unreinforced presentation over several days. We report that this extinction is long-lasting and generalises to other contexts, but can be rapidly recovered via the pairing of the visual stimulus with an aversive electric foot-shock stimulus. Moreover, fiber photometric recordings reveal that this behavioural paradigm results in the attenuation of SC and PAG physiological responses to visual looming stimuli, and that these responses do not recover following recovery of behavioural responses. An analysis of c-Fos expression patterns throughout the midbrain and hippocampus uncovered a ventral CA1 (vCA1) ensemble that is active during both innate and learned visual looming fear responses. We investigate the functional significance of this vCA1 ensemble and report that, while its activity is not necessary for innate defensive behaviour, it is necessary for learned fear responses. Together, these findings reveal a novel role of the hippocampus in enabling adaptive behavioural responses to the innately threatening visual looming stimulus which acts in complement with innate circuitry of the SC and PAG. ### Competing Interest Statement The authors have declared no competing interest.
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Ghandralph

Only three weeks into my 3D printing “career” I uploaded my first simple creation to makerworld.com. A small stand for small to medium size LEGO models of air/spacecraft.

What is special about it is that the models can be displayed at a (fixed) roll and pitch angle of 25 degrees. Making the display much more exciting.

created with Plasticity

Here’s the direct link to it: makerworld.com/en/models/81501

#3dprinting#plasticity#BambuLab
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Meuthen IDEA LAB

We applaud our student Dustin Raeke for finishing his Research module in our lab titled "Environmental effects on gastropod personality". His great efforts allowed him to study behavioral repeatability in 166 snails across two environments by conducting a whopping 830 experiments. Look forward to reading more about his results in a publication that will be prepared in the near future! #ecology #evolution #personality #plasticity #gastropods @academicchatter

Smiling young white male in front of an orange background with short brown hair and glasses.
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