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#evodevo

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Una

@futurebird such a cool question! I haven’t followed this field for ages so maybe wrong. All vertebrates and most invertebrates are bilatarians which are metazoans with bilateral symmetry, meaning they have developed around a longitudinal body with a head and tail. So that basic body plan likely come from a common ancestor but details like eyes or eye stalks, like you mentioned can be from parallel evolution. #evodevo folks would know the more current thinking around this.

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ZooCELL MSCA-Doctoral network

More #introduction about our ZooCELL network.

We will do a lot of volume electron #microscopy #volumeEM focusing on sensory systems in marine #animals

We will combine this with single-cell #genomics, correlative LM/EM, #AI -based image segmentation and classification, and genetics

You can read more about the participating labs here:

zoocell.eu/consortium/#Benefic

We will post about events, projects etc. in the coming years.
If you like #zoology #evodevo #marine #biology follow/boost us!

Public
ZooCELL MSCA-Doctoral network

More #introduction about our network.

We will do a lot of volume electron #microscopy #volumeEM focusing on sensory systems in marine #animals

We will combine this with single-cell #genomics, correlative LM/EM, #AI -based image segmentation and classification, and genetics

You can read more about the participating labs here:

zoocell.eu/consortium/#Benefic

We will post about events, projects etc. in the coming years.
If you like #zoology #evodevo #marine #biology follow/boost us!

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Mauricio González-Forero

Our revised preprint following peer-review: “Why did the human brain size evolve: a way forward”. We suggest a simulation-based inference approach to infer why the human brain size evolved.
ecoevorxiv.org/repository/view

Illustrating this approach, we analyse a model that recovers major patterns of human development and evolution.

We discuss how, counter-intuitively, the human brain size, seemingly one of the most extraordinary existing adaptations, is not an adaptation in the model but a spandrel or by-product of selection for something else.

This finding refers to what the human brain size is in *this* model, not necessarily in reality. We suggest that a simulation-based inference approach could now be pursued to inferring what the human brain size is in reality, not just in one model.

ecoevorxiv.orgWhy did the human brain size evolve? A way forward
#evolution#evodevo#math
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Max, whispers to you too now

I need help finding a paper I read years ago. It's a bit niche but maybe someone can help

The papers was about Strepsiptera, explaining how they repurpose typical metamorphosis genes to have a ''second'' metamorphosis in their life cycle.

I am not sure if that was the main point of the paper, as looking for it through this angle I can't find it, but it was definitely there.

If that rings a bell, let me know! If you have another example, I'm also a bit interested

#insects#evodevo#librarians
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Marc Robinson-Rechavi

Very interesting preprint by @jkpritch lab on non monotonous relation between phenotype and gene expression, relevant to #MolecularEvolution and #EvoDevo (and human medicine I suppose 😉)
medrxiv.org/content/10.1101/20

medRxiv · Buffering and non-monotonic behavior of gene dosage response curves for human complex traitsThe genome-wide burdens of deletions, loss-of-function mutations, and duplications correlate with many traits. Curiously, for most of these traits, variants that decrease expression have the same genome-wide average direction of effect as variants that increase expression. This seemingly contradicts the intuition that, at individual genes, reducing expression should have the opposite effect on a phenotype as increasing expression. To understand this paradox, we introduce a concept called the gene dosage response curve (GDRC) that relates changes in gene expression to expected changes in phenotype. We show that, for many traits, GDRCs are systematically biased in one trait direction relative to the other and, surprisingly, that as many as 40% of GDRCs are non-monotone, with large increases and decreases in expression affecting the trait in the same direction. We develop a simple theoretical model that explains this bias in trait direction. Our results have broad implications for complex traits, drug discovery, and statistical genetics. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement N.M. was supported by a National Science Foundation Graduate Research Fellowship and Stanford's Knight-Hennessy Scholars Program. C.J.S. was supported by Stanford's Knight-Hennessy Scholars Program and the Stanford Center for Computational, Evolutionary and Human Genomics. H.Z. was supported by Stanford Biology Department's graduate student assistantship. This work was supported by the National Institutes of Health (R01HG011432 and R01HG008140 to J.K.P.). ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: UK Biobank has approval from the North West Multi-centre Research Ethics Committee (MREC) as a Research Tissue Bank (RTB) approval. This approval means that researchers do not require separate ethical clearance and can operate under the RTB approval. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes All genetic and health data was acquired from the UK Biobank, a biomedical database containing information from half a million UK participants. Data for genetic association analysis of continuous traits was acquired under application 52374. Data for genetic association analysis of metabolite traits was acquired under application 30418. These data are available upon application to the UK Biobank. All summary statistics generated from genetic association analysis and other processed data files are deposited in Zenodo. <https://doi.org/10.5281/zenodo.13852455> <https://www.ukbiobank.ac.uk/>
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Bruno C. Vellutini

EvoDevo Papers now at biologists.social

The botsin.space community, a popular Mastodon server for automated accounts (bots), will be retiring soon. They have been kindly hosting EvoDevo Papers for the past couple of years.

To avoid any downtime, I recently migrated the account to a new server, the biologists.social community managed by The Company of Biologists. I think it’s a great match, and I’m glad they agreed to host. The new address is:

@evodevo_papers@biologists.social

The migration went well and posting has already resumed. I’ve also taken the chance to tweak the website and refactor the code base to pave the way for novel features that I’m planning to implement. Just released v2.2.0 🎉

Screenshot of EvoDevo Papers home page, showing the title/tagline and a list of links to the latest papers.
#django#evoDevo#python
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📑 EvoDevo Papers

Hi! I'm a bot that shares research papers in EvoDevo (or Evolutionary Developmental Biology).

Currently, I index a few journals in the field and post links to articles that were published recently, one per day.

Since my posts are set to “quiet public”, they don't appear on Mastodon's feeds or hashtags searches. So, please, boost the papers you find worth sharing!

Any feedback is welcome. Thanks :)

#Introduction#EvoDevo#Papers
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Marc Robinson-Rechavi

Very happy to see this work out, after a ton of work by Giulia Zancolli @dee_unil and collaborators. Cone snails are venomous 🐚🍽️🐟 and have evolved from non venomous marine snails. How did their venom gland evolve from homologous glands, and how did this affect the evolution of their digestive system? That’s what you’ll find our by reading our preprint! 😀
biorxiv.org/content/10.1101/20
#venom #snail #evodevo

Left: overview of the anatomy of a marine snail, with color-coded sampled tissues: salivary glands, foot, gland, oesophagus, and columellar muscle Right: phylogeny of the marine snails used in the study, showing different gland phenotypes in different species: oesophageal gland, gland of Leiblein, no gland, and venom gland with muscular bulk
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