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#genomeediting

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Amelia Cervera 🧬

Precise deletion, replacement and inversion of large DNA fragments in plants using dual prime editing.
#GenomeEditing #Plants #PrimeEditing
nature.com/articles/s41477-024

www.nature.comPrecise deletion, replacement and inversion of large DNA fragments in plants using dual prime editing | Nature PlantsPrecise manipulation of genome structural variations holds great potential for plant trait improvement and biological research. Here we present a genome-editing approach, dual prime editing (DualPE), that efficiently facilitates precise deletion, replacement and inversion of large DNA fragments in plants. In our experiments, DualPE enabled the production of specific genomic deletions ranging from ~500 bp to 2 Mb in wheat protoplasts and plants. DualPE was effective in directly replacing wheat genomic fragments of up to 258 kb with desired sequences in the absence of donor DNA. Additionally, DualPE allowed precise DNA inversions of up to 205.4 kb in wheat plants with efficiencies of up to 51.5%. DualPE also successfully edited large DNA fragments in the dicots Nicotiana benthamiana and tomato, with editing efficiencies of up to 72.7%. DualPE thus provides a precise and efficient approach for large DNA sequence and chromosomal engineering, expanding the availability of precision genome-editing tools for crop improvement. This study explores a precise and efficient chromosome editing technology that enables the scarless deletion, replacement and inversion of large DNA fragments, up to the megabase scale, in plants and holds considerable promise for crop improvement.
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EMBL Events

Did you apply for our #EMBLCRISPRcas course already? 👀
If not, then hurry up and do it by 9 June: 👉s.embl.org/gee24-01

Don't miss the opportunity to advance your skills in genome editing and cell engineering with this comprehensive hands-on training 🧬✂️

Read an interview of attendee Luigi Devis about our last CRISPR/Cas Course: ➡️ s.embl.org/CRISPRinterview
#EMBLEvents #EMBL #lifesciencetraining #genome #CRISPR #geneediting #gRNA #Cas9 #genomeediting xn--s-f52s.embl.org/gee24-01

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ALLEA - All European Academies

[📢 NEW STATEMENT]
How do current IP regulations impact the development and use of New Genomic Techniques (NGTs) for crop breeding in Europe?

ALLEA released a new statement addressing concerns surrounding the impact of the current intellectual property system on the adoption and development of New Genomic Techniques for crop breeding. 🌱 Read more: allea.org/allea-releases-state

📅 Join the discussion on 6/03, 14:00 CET ➡️ allea.org/webinar-impact-of-th
#genomeediting #crop #ngt #ip #webinar #statement

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