Create accountLogin

Recent searches

No recent searches

Search options

Only available when logged in.
mathstodon.xyz is one of the many independent Mastodon servers you can use to participate in the fediverse.
A Mastodon instance for maths people. We have LaTeX rendering in the web interface!

Administered by:

Server stats:

2.8K
active users

mathstodon.xyz: AboutStatusProfiles directoryPrivacy policy

Mastodon: AboutGet the appKeyboard shortcutsView source codev4.3.7

#diapause

0 posts0 participants0 posts today
Replied in thread
Public
Albert Cardona

@flypapers

The potential for lab fly husbandry are high:

"By late August, most adults are in diapause and reproduction ceases. Like many species of Drosophila in temperate regions, there may be only one generation produced per year. This is likely facilitated by the ability to diapause."

Imagine enabling a Drosophila melanogaster to "diapause" in the freezer instead of having to actively maintain their populations by flipping their bottles into new food every two weeks.

The savings by the Bloomington Drosophila Stock Center alone would be huge.

#Drosophila#diapause#flyhusbandry
Public
Biology Open

In this article, Sophie Kraunsoe et al. explore the role of STAT3 and TFCP2L1 in #epiblast renewal, and find that requirements for stem cell #renewal in the dish are different to those in the #embryo:

journals.biologists.com/bio/ar

Check out this interview with Sophie to find out more about the story behind the paper:
journals.biologists.com/bio/ar

Left panel: Sophie Kraunsoe. Right panel: differentiating human pluripotent stem cells expressing Nanog (cyan) and pERM (magenta), stained using phalloidin (green) and DAPI (grey).
#Pluripotency#Diapause#Blastocyst
Public
Aging Highlights

Diapause is a model for lifespan plasticity in Drosophila melanogaster: A Multiomic Analysis

#diapause #drosophila #aging
#omics

biorxiv.org/content/10.1101/20

bioRxivMultiomic Analysis of Adult Diapause in Drosophila melanogaster Identifies Hallmarks of Cellular QuiescenceAge is a fundamental aspect of biology that underlies the efficacy of a broad range of functions. Identifying determinants for how quickly or slowly we age will contribute greatly to our understanding of age as a modifier of overall health, particularly to the advancement of therapeutic interventions designed to mitigate or delay age-associated disorders. While much work has been devoted to the study of genetic or pharmacological interventions that extend lifespan, this approach does not necessarily recapitulate the physiological profile of naturally long-lived individuals. Diapause and diapause-like states constitute natural, inducible and evolutionarily conserved examples of lifespan plasticity that are well-suited to serve as physiologically accurate models of longevity. Here, we leveraged a metabolically critical signaling organ in Drosophila, the fat body, to examine diapause-associated transcription in the context of chromatin accessibility and the regulation of lifespan. Through a combination of ATAC-seq and RNA-seq, our observations suggest chromatin is globally reorganized in diapause and may assume a poised conformation to facilitate the rapid transcription of pro-development genes upon diapause termination. We found particular significance of GAF, NELF, and RNA polymerase III in this context. Congruently, transcription during diapause appears to favor many processes supporting the maintenance of cellular quiescence and the inhibition of differentiation. Our data are consistent with a model wherein diapause induces cellular quiescence in the fat body, as was additionally supported through fluorescent microscopy and comparison with public ChIP-seq data for developmentally juvenile files. This work opens the possibility that longevity in diapause may be partially determined through a lack of mitogenic signaling from the quiescent niche, concurrent with changes to the hormonal and immunological profiles that skew metabolism towards tissue maintenance. ### Competing Interest Statement The authors have declared no competing interest.
SearchLive feeds
About