Get your data out now!

BMC has a special edition on “The Extracellular Matrix,” and I’m honoured to guest edit. We’re accepting manuscripts on all aspects of ECM, but if you know my background, you’ll know I’m especially excited about structural data and collagens .

BMC has a solid JIF and welcomes all scientifically valid studies—so write up your story now and submit!

DM me if you have questions or check out https://www.biomedcentral.com/collections/ECM

Filamentous Phage Shields https://schaechter.asmblog.org/schaechter/2024/03/filamentous-phage-shields.html @STCmicrobeblog

Phage liquid crystalline droplets form occlusive sheaths that encapsulate and protect infectious rod-shaped #bacteria (2020) https://www.pnas.org/doi/full/10.1073/pnas.1917726117

"in #biofilms and due to the presence of #ExtracellularMatrix #polymers, Pf4 #phage particles form highly ordered yet dynamic #LiquidCrystals (tactoids) that surround the cells. Quite interestingly, these #tactoids confer on the cells an increased tolerance to #antibiotics."

Folded membrane microdomains between the cuticle and epidermis called 'meisosomes' have a role in maintaining and patterning these structures in #CElegans. and its connection with the #ExtracellularMatrix. https://elifesciences.org/articles/75906?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Four good things happened at work today. Almost unheard of.

Two great bits of new data. #cilia #Golgi #ExtracellularMatrix
One modified piece of equipment that means we can do some cool new experiments.
And I got some code to run a mathematical model given to us by a collaborator. New software. Step learning curve.

Worth remembering days like these. They do still happen!

Through the eyes of an #osteocyte. In #bone, this is what the environment of partially embedded osteocytes (osteoblastic–osteocytes) is like!

Scanning electron microscopy has been used to observe the orientation of mineral platelets in relation to osteoblastic–osteocyte lacunae on the surface of deproteinized trabecular bone in adult sheep.

Read more:
https://doi.org/10.1007/s00223-015-0072-8

@zeiss_micro #microscopy #biology #imaging #biomineralization #extracellularmatrix #friday

During development, #Netrin1 is released and diffusible in the microenvironment. This study shows that in #cancer, #Netrin1 accumulates in the #ExtracellularMatrix. The authors used this property to follow its in vivo accumulation by radiolabeling and to target netrin-1-expressing tumor cells with #radioimmunotherapy.

By D. Kryza, P. Mehlen, D. Sarrut, B. Gibert & colleagues

Full #openaccess article : https://doi.org/10.15252/emmm.202216732

Great review from Nicola Stevenson. Part of our team in Biochemistry at the U of Bristol researching #Golgi #cilia and #extracellularmatrix

https://journals.biologists.com/bio/article/12/2/bio059719/287059/The-factory-the-antenna-and-the-scaffold-the-three

Part of Biology Open's series of Future Leader Reviews. @BiologyOpen

Nikki is making great progress on our @BBSRC sLoLa.
This review includes some thoughts beyond her current work towards more integration with cilia biology.

Preprint

Full-length αIIbβ3 #CryoEM structure reveals intact integrin initiate-activation intrinsic architecture

#StructuralBiology @strucbio
#ExtracellularMatrix #Research
http://biorxiv.org/cgi/content/short/2022.12.19.520944v1?rss=1

#introduction:
We are a new cell systems biology team at the #UniversityOfManchester #UoM.
We study #CellAdhesion #networks in health and disease, especially #cancer.
Fascinated by how adhesion proteins help #cells function in so many ways!

Hi all, I'm a Principal (Laboratory Research Scientist/Scientific officer) at the Francis Crick Institute in #London, #UK.

I am a structural biologist ( #Crystallography and #CryoEM ), and the group I help run studies kinase signalling in a few different contexts in human health and disease. I am interested in #Glycobiology, #DrugDesign, #ExtracellularMatrix and various #Biophyisics methods.

I will also moan about #UKPolitics. Sorry.