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fc5 days til 💉💥🩻. 😱 <a href="https://universeodon.com/tags/pain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#pain</a> <a href="https://universeodon.com/tags/anesthesia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#anesthesia</a> <a href="https://universeodon.com/tags/steroid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#steroid</a> <a href="https://universeodon.com/tags/injection" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#injection</a> <a href="https://universeodon.com/tags/XRay" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#XRay</a> (I know - it's a new one on me, too.)

Mandy Watson27 hours without sleep, thanks to the steroid knee injection. My personal record for someone who needs 10 hours a night. The doctor forgot to mention insomnia is common and can last 1-3 days! I feel like I've drunk gallons of expresso.<a href="https://mastodon.social/tags/steroid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#steroid</a> <a href="https://mastodon.social/tags/steroidinjection" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#steroidinjection</a> <a href="https://mastodon.social/tags/arthritis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#arthritis</a> <a href="https://mastodon.social/tags/osteoarthritis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#osteoarthritis</a> <a href="https://mastodon.social/tags/kneearthritis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#kneearthritis</a> <a href="https://mastodon.social/tags/corticosteroids" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#corticosteroids</a>

Ozzie D, NP-hard :bikepump: :vegan:{Acronym alert - glossary at bottom.} I see more <a href="https://infosec.exchange/tags/asthma" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#asthma</a> patients getting bumped from ICS-only monotherapy (and/or SABA-only rescue med) to combo ICS-LABA inhalers. This is spurred by GSK discontinuing brand-name Flovent, and GINA guidelines promoting AIR and MART (aka SMART) strategy, which utilizes a combo inhaler containing formoterol, like Symbicort, Breyna, or Dulera. This is a big change for many people, who're used to using an inhaled <a href="https://infosec.exchange/tags/steroid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#steroid</a> for control and prevention, and inhaled <a href="https://infosec.exchange/tags/albuterol" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#albuterol</a> for rapid relief. Now they can use one inhaler for both -- which is convenient, and may bring better control.Explainer "What is SMART Therapy for Asthma?": <a href="https://allergyasthmanetwork.org/news/asthma-smart-therapy/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://allergyasthmanetwork.org/news/asthma-smart-therapy/</a>Now I'm also seeing PCPs, pediatricians, and pulmonologists prescribing other combo ICS-LABA inhalers like Advair with a SMART asthma action plan -- even though that's not approved under GINA or NAEPP guidelines. In fact they explicitly warn against this: "Combination ICS with non-formoterol LABA cannot be used as-needed for symptom relief." (GINA main report, p. 69). LABAs like salmeterol (more lipophilic) take much longer to kick in (30+ minutes) to be intended for rapid relief, and have not been studied for rescue use. But they're being prescribed that way anyway, presumably due to availability, insurance coverage, and clinician confusion during a time of flux. Leading to a lot of follow-up conversations. :blobcatshrug:GINA 2023 main report: <a href="https://ginasthma.org/wp-content/uploads/2023/07/GINA-2023-Full-report-23_07_06-WMS.pdf" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://ginasthma.org/wp-content/uploads/2023/07/GINA-2023-Full-report-23_07_06-WMS.pdf</a> .NIH NAEPP 2020 Asthma Guidelines: <a href="https://www.jacionline.org/article/S0091-6749(20)31404-4/fulltext" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.jacionline.org/article/S0091-6749(20)31404-4/fulltext</a>Glossary (in no order):<ul><li>ICS == inhaled corticosteroid (Flovent, QVAR). Steroids reduce airway inflammation slowly over time.</li><li>SABA == short-acting beta-agonist: a bronchodilator (canonically albuterol) that quickly relieves airway constriction, for a few hours.</li><li>LABA == long-acting beta-agonist (ex: salmeterol, formoterol), relieves airway symptoms for more than a few hours.</li><li>Rescue med, aka "reliever" == a rapid-acting drug to relieve acute symptoms (e.g. albuterol, epinephrine).</li><li>Maintenance therapy == drug you take daily to prevent acute symptoms.</li><li>Monotherapy == managing a disease with just one drug.</li><li>AIR == Anti-Inflammatory Reliever: combo inhaler with a low-dose steroid + a rapid-acting bronchodilator</li><li>MART == Maintenance And Reliever Therapy: treatment with an inhaler that contains both a steroid and a rapid-onset, long-acting beta-agonist (formoterol). Also called SMART (S == "Single-inhaler").</li><li>GINA == Global Initiative on Asthma</li></ul><a href="https://infosec.exchange/tags/MedMastodon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MedMastodon</a> <a href="https://infosec.exchange/tags/pulmonology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#pulmonology</a> <a href="https://infosec.exchange/tags/pediatrics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#pediatrics</a>

Al<a href="https://universeodon.com/@georgetakei" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@georgetakei</a> We need to start testing US <a href="https://mastodon.sdf.org/tags/senators" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#senators</a> for <a href="https://mastodon.sdf.org/tags/steroid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#steroid</a> use. There seems to be long term negative effects on their <a href="https://mastodon.sdf.org/tags/commonSense" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#commonSense</a>.

Alexey VeraksaDepending on ligand concentration, <a href="https://drosophila.social/tags/Drosophila" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Drosophila</a> ecdysone (<a href="https://drosophila.social/tags/steroid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#steroid</a>) receptor can either promote or inhibit proliferation. <a href="https://drosophila.social/tags/DevBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#DevBio</a> <a href="https://doi.org/10.1016/j.devcel.2023.08.032" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://doi.org/10.1016/j.devcel.2023.08.032</a>

The EMBO JournalPlacing <a href="https://sciencemastodon.com/tags/steroid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#steroid</a> hormones within the human <a href="https://sciencemastodon.com/tags/ABCC3" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ABCC3</a> transporter reveals a compatible amphiphilic substrate-binding pocket This <a href="https://sciencemastodon.com/tags/cryoEM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cryoEM</a> study uses the location of two substrates to reveal a common steroid-binding pocket <a href="https://www.embopress.org/doi/full/10.15252/embj.2022113415" rel="nofollow noopener noreferrer" target="_blank">https://www.embopress.org/doi/full/10.15252/embj.2022113415</a>

Vivienne DunstanMay is <a href="https://mastodon.scot/tags/vasculitis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#vasculitis</a> awareness month. Vasculitis is a <a href="https://mastodon.scot/tags/rare" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#rare</a> <a href="https://mastodon.scot/tags/autoimmune" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#autoimmune</a> <a href="https://mastodon.scot/tags/disease" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#disease</a> that causes <a href="https://mastodon.scot/tags/inflammation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inflammation</a> in the <a href="https://mastodon.scot/tags/blood" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#blood</a> vessels, anywhere in the body. Here is my story, since 1994, when it started attacking my <a href="https://mastodon.scot/tags/brain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#brain</a>. Years on I'm lucky to be here. My case is progressive, a cross between strokes and multiple sclerosis like symptoms. Read my story of wrong initial <a href="https://mastodon.scot/tags/diagnosis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#diagnosis</a>, long term <a href="https://mastodon.scot/tags/steroid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#steroid</a> and <a href="https://mastodon.scot/tags/chemotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#chemotherapy</a> treatment, and basically surviving. <a href="https://www.vasculitis.org.uk/living-with-vasculitis/vivs-story" rel="nofollow noopener noreferrer" target="_blank">https://www.vasculitis.org.uk/living-with-vasculitis/vivs-story</a> <a href="https://mastodon.scot/tags/neuro" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuro</a> <a href="https://mastodon.scot/tags/medicine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#medicine</a> <a href="https://mastodon.scot/tags/health" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#health</a>

Scientific Frontline<a href="https://mastodon.social/tags/Steroid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Steroid</a> <a href="https://mastodon.social/tags/hormones" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hormones</a>, to which belong <a href="https://mastodon.social/tags/sex" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#sex</a> hormones like <a href="https://mastodon.social/tags/estrogen" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#estrogen</a> or <a href="https://mastodon.social/tags/testosterone" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#testosterone</a>, are important signaling <a href="https://mastodon.social/tags/molecules" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#molecules</a> and are responsible among other things for controlling female and male phenotypic sex differentiation. <a href="https://mastodon.social/tags/Biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Biology</a> <a href="https://mastodon.social/tags/Medical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Medical</a> <a href="https://mastodon.social/tags/sflorg" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#sflorg</a> <a href="https://www.sflorg.com/2023/03/bio03272304.html" rel="nofollow noopener noreferrer" target="_blank">https://www.sflorg.com/2023/03/bio03272304.html</a>

ArtofCyclingAnother sign of <a href="https://mastodon.world/tags/aging" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#aging</a>, I'm sitting at the <a href="https://mastodon.world/tags/podiatrist" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#podiatrist</a> waiting to have <a href="https://mastodon.world/tags/steroid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#steroid</a> injections into both of my <a href="https://mastodon.world/tags/feet" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#feet</a>. <a href="https://mastodon.world/tags/bartenderlife" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#bartenderlife</a> <a href="https://mastodon.world/tags/hardwork" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hardwork</a> I sure hope it solves the problem, the surgical option doesn't sound great. I may be spending way too much time standing up.

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