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Szymon Bęczkowski"Scientists aiming to bring back woolly mammoth create woolly mice". This is what happens when you underfund <a href="https://en.osm.town/tags/academia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#academia</a>. Wool but <a href="https://en.osm.town/tags/inmice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inmice</a>. <a href="https://www.theguardian.com/science/2025/mar/04/genetically-modified-woolly-mice-mammoth" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.theguardian.com/science/2025/mar/04/genetically-modified-woolly-mice-mammoth</a>

Dr. Anna LatourI'm in a friend group where people regularly share articles and TikToks etc claiming all kinds of findings.I am that person who then tries to find the sources of the original information, then reads academic papers to gauge if the "headlines" that are shared can actually backed up by proper science.In this process, I often find myself uttering the words "I hate to be this person again, but... *in mice*. They did *one* small study with *mice* and found an effect *in mice*."I love this.<a href="https://www.theguardian.com/science/2025/mar/04/genetically-modified-woolly-mice-mammoth" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://www.theguardian.com/science/2025/mar/04/genetically-modified-woolly-mice-mammoth</a><a href="https://mathstodon.xyz/tags/Science" class="mention hashtag" rel="tag">#Science</a> <a href="https://mathstodon.xyz/tags/InMice" class="mention hashtag" rel="tag">#InMice</a> <a href="https://mathstodon.xyz/tags/Mice" class="mention hashtag" rel="tag">#Mice</a> <a href="https://mathstodon.xyz/tags/Mammoth" class="mention hashtag" rel="tag">#Mammoth</a> <a href="https://mathstodon.xyz/tags/WoollyMammoth" class="mention hashtag" rel="tag">#WoollyMammoth</a>

Mike Malaska<a href="https://mastodon.social/@TCatInReality" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@TCatInReality</a> <a href="https://social.linux.pizza/@marjolica" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@marjolica</a> <a href="https://zirk.us/@ChrisMayLA6" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@ChrisMayLA6</a> (those are very old numbers, btw. Prolly double now.)At each step, about 50% attrition. (This is why press releases finding something active <a href="https://deepspace.social/tags/InMice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#InMice</a> is so silly.)So it COSTS $620 million to find a new drug if everything works.How much do pharma companies actually SPEND to find a new drug? (So include failure costs)Turns out about $8B per drug. (Reported R&D costs per new drug approval)

Joe VilasStudy in mice, but "Early life exposure to 'forever chemicals' in the environment permanently disrupts the gut microbiome" <a href="https://www.psu.edu/news/research/story/early-life-exposure-common-chemical-permanently-disrupts-gut-microbiome/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.psu.edu/news/research/story/early-life-exposure-common-chemical-permanently-disrupts-gut-microbiome/</a> <a href="https://triangletoot.party/tags/TCDF" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TCDF</a> <a href="https://triangletoot.party/tags/health" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#health</a> <a href="https://triangletoot.party/tags/inMice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inMice</a> <a href="https://triangletoot.party/tags/medicine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#medicine</a> <a href="https://triangletoot.party/tags/bioChemistry" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#bioChemistry</a> <a href="https://triangletoot.party/tags/foreverChemicals" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#foreverChemicals</a>

charisOK, today I learned that even <a href="https://mastodon.social/tags/InMice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#InMice</a> is an inadequate addition to mainstream articles about pre-clinical research.Turns out it needs to be In *Male* Mice<a href="https://www.theguardian.com/science/article/2024/jul/22/sex-bias-labs-women-losers-research-ageing" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.theguardian.com/science/article/2024/jul/22/sex-bias-labs-women-losers-research-ageing</a>SighAn explainer for <a href="https://mastodon.social/tags/JustSaysInMice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#JustSaysInMice</a> if you've not come across it before <a href="https://jamesheathers.medium.com/in-mice-explained-77b61b598218" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://jamesheathers.medium.com/in-mice-explained-77b61b598218</a><a href="https://mastodon.social/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#research</a> <a href="https://mastodon.social/tags/journalism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#journalism</a>

chris@strafpla.netFishermens gegen <a href="https://mstdn.strafpla.net/tags/Alzheimer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Alzheimer</a>? <a href="https://mstdn.strafpla.net/tags/inMice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inMice</a> <a href="https://mstdn.strafpla.net/tags/Menthol" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Menthol</a> <a href="https://doi.org/10.3389/fimmu.2023.1130044" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://doi.org/10.3389/fimmu.2023.1130044</a>

Elias Probst<a href="https://noc.social/@todayilearned" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@todayilearned</a> Where's the <a href="https://mastodon.social/tags/InMice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#InMice</a> account when we need it?

Professor Lesley HoylesMicrobial dietary protein metabolism regulates GLP‐1 mediated intestinal transit <a href="https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202300982R" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202300982R</a><a href="https://mastodon.social/tags/inmice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inmice</a> <a href="https://mastodon.social/tags/microbiome" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#microbiome</a>

Albert Cardona<a href="https://mathstodon.xyz/@maxpool" class="u-url mention">@maxpool</a> <a href="https://mathstodon.xyz/tags/InMice" class="mention hashtag" rel="tag">#InMice</a>

Colin D. Wren"Using AI, scientists bring Neanderthal antibiotics back from extinction" what a bizarre story <a href="https://fediscience.org/tags/InMice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#InMice</a> <a href="https://www.vox.com/future-perfect/23811682/ai-neanderthal-antibiotics-extinction" rel="nofollow noopener noreferrer" target="_blank">https://www.vox.com/future-perfect/23811682/ai-neanderthal-antibiotics-extinction</a>

John RefiorI like that this article links to a number of related sources. And what do they do with all the female mice that are born?"The female presence in labs is completely under-represented, and I'm not talking about humans here, but mice. The most used animal model in laboratories across the world to discover and test new medicines are almost entirely male." <a href="https://www.understandinganimalresearch.org.uk/news/why-we-need-female-mice-in-drug-trials" rel="nofollow noopener noreferrer" target="_blank">https://www.understandinganimalresearch.org.uk/news/why-we-need-female-mice-in-drug-trials</a> -- <a href="https://hachyderm.io/tags/InMice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#InMice</a>

John RefiorBack before <a href="https://hachyderm.io/tags/EmperorPayPaltine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#EmperorPayPaltine</a>, one of my favorite <a href="https://hachyderm.io/tags/Twitter" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Twitter</a> accounts was @inmice (<a href="https://hachyderm.io/tags/InMice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#InMice</a>). Whenever someone posted a media article saying something about human health when it was actually based only on studying mice, it would reply with just this text:IN MICE

Jennifer Bussell Ph.D.Hi all! By way of <a href="https://fediscience.org/tags/introduction" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#introduction</a>, I'm a postdoctoral <a href="https://fediscience.org/tags/neuroscientist" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuroscientist</a> in the Axel Lab at Columbia University's Zuckerman Institute. I study information seeking, knowledge as motivation, and <a href="https://fediscience.org/tags/curiosity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#curiosity</a> <a href="https://fediscience.org/tags/inmice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inmice</a> using olfactory stimuliI hope to have my own lab soon to answer questions like "Why and how are humans and animals motivated to learn about the world?"I care a lot about the structural issues keeping <a href="https://fediscience.org/tags/academic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#academic</a> <a href="https://fediscience.org/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#science</a> from being inclusive and equitable.<a href="https://fediscience.org/tags/neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuroscience</a>

Andrew TarantolaA newly published study in Nature suggests that the constitution of you gut biome could have an impact on your neurological performance and susceptibility to degenerative diseases like <a href="https://masto.ai/tags/Alzheimers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Alzheimers</a>. Take it with a grain of salt as it's an <a href="https://masto.ai/tags/InMice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#InMice</a>, but the results could eventually lead to methods of affecting brain chemistry without having to hurdle the BBB. <a href="https://neurosciencenews.com/gut-bacteria-brain-health-22237/" rel="nofollow noopener noreferrer" target="_blank">https://neurosciencenews.com/gut-bacteria-brain-health-22237/</a><a href="https://masto.ai/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#science</a> <a href="https://masto.ai/tags/health" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#health</a> <a href="https://masto.ai/tags/neurology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neurology</a> <a href="https://masto.ai/tags/brain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#brain</a>

Mike Malaska<a href="https://fediscience.org/@Ruth_Mottram" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@Ruth_Mottram</a> Drug discovery is humbling. 95% of all drug discovery efforts fail.For Alzheimer's, it's 100%. Despite 30+ years of intense research and trillions likely thrown at AD.(And there is also a reason that <a href="https://deepspace.social/tags/InMice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#InMice</a> is a thing. Overhyped non-human results are a major problem. There have been 30 years of "shows promise as a cure" without delivery.)Multiple new approaches are a good thing. Throw everything and the kitchen sink at it.

Dan SugalskiThis is still an <a href="https://weatherishappening.network/tags/InMice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#InMice</a> thing, but if this study pans out in people it'll be an awesome thing for folks with Lupus. (I'm also curious if it's true for patients with other autoimmune diseases, but that'd just be a bonus tbh)<a href="https://www.eurekalert.org/news-releases/974397" rel="nofollow noopener noreferrer" target="_blank">https://www.eurekalert.org/news-releases/974397</a>

Dr. Cate<a href="https://qoto.org/@biorxivpreprint" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@biorxivpreprint</a> Congrats to postdoc Julie-Anne Balouek on her latest manuscript! This is the first paper from only my lab which we are so proud to share for your holiday reading. We find that neurons activated by <a href="https://genomic.social/tags/earlylifestress" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#earlylifestress</a> are preferentially *reactivated* by adult stress, particularly in NAc, and that quieting this hypersensitivity at a cellular level also ameliorates behavior <a href="https://genomic.social/tags/inmice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inmice</a>

Thiago CarvalhoDelivering ICIs to the brain<a href="https://qoto.org/tags/InMice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#InMice</a> "Assessment of the BBB/BTB physical and molecular properties, anti-PD1 penetration and uptake, and its impact on immune cell trafficking, along with monitoring of treatment response rates and durability are used to test our hypothesis and support the effective integration and translation to the clinics of brain cancer immunotherapy with MB-FUS and immune checkpoint blockade."<a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/Immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunotherapy</a><a href="https://www.science.org/doi/10.1126/sciadv.add2288" rel="nofollow noopener noreferrer" target="_blank">https://www.science.org/doi/10.1126/sciadv.add2288</a>

Dr. CateThe Peña Lab is HIRING! Currently seeking 1-2 <a href="https://genomic.social/tags/postdocs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#postdocs</a> (molecular or <a href="https://genomic.social/tags/datascientists" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#datascientists</a>) for multiple funded projects to understand how <a href="https://genomic.social/tags/earlylifestress" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#earlylifestress</a> impacts <a href="https://genomic.social/tags/epigenetic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#epigenetic</a> regulation of brain development and behavior. We use <a href="https://genomic.social/tags/singlecell" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#singlecell</a> and other <a href="https://genomic.social/tags/sequencing" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#sequencing</a> approaches, computational analyses, and test our hypotheses back in vivo by gene and epigenome editing, activity manipulations, and pharmacological approaches - and of course behavior <a href="https://genomic.social/tags/inmice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inmice</a>.More here --> www.PenaLab.org

Daniel Probst"Genesis of fecal floatation is causally linked to gut microbial colonization in mice"At least in mice, we may finally know what makes floaters float. It's all about the bacteria in the gut.<a href="https://www.nature.com/articles/s41598-022-22626-x" rel="nofollow noopener noreferrer" target="_blank">https://www.nature.com/articles/s41598-022-22626-x</a><a href="https://skepteis.social/tags/Science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Science</a> <a href="https://skepteis.social/tags/Biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Biology</a> <a href="https://skepteis.social/tags/InMice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#InMice</a>

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