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#neuron

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"In mice, here we reveal a non-pyramidal excitatory neuron type — the “ovoid” neuron — that is spatially adjacent to subiculum pyramidal cells but differs in gene expression, electrophysiology, morphology, and connectivity. Functionally, novel object encounters drive sustained ovoid neuron activity, whereas familiar objects fail to drive activity even months after single-trial learning."

nature.com/articles/s41467-025

NatureAtypical hippocampal excitatory neurons express and govern object memory - Nature CommunicationsPyramidal cells are classically thought to comprise the excitatory output of the subiculum. Here, the authors show the existence of “ovoid cells”, excitatory subiculum neurons with specialized gene expression, morphology, projections, and function.
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#NeuroML supports all stages of the modelling life-cycle with a vast ecosystem of software tools: creating (#pyNeuroML, #neuroConstruct, #NEURON, #NetPyNE, #PyNN, #N2A), validating (pyNeuroML, #OMV, #SciUnit), visualising (pyNeuroML, #OSB, #NeuroML-DB), simulating (#NEURON, #NetPyNE, #Brian, #PyNN, #NEST, #MOOSE, #EDEN), model fitting/optimisation (#NeuroTune, #BluePyOpt, NetPyNE), sharing and reusing of models (OSB, NeuroML-DB, #NeuroMorpho.org). 7/x

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A number of software tools are available for construction and simulation of models: #NEURON, #NetPyNE, #Brian, #PyNN, #NEST, #MOOSE, #EDEN etc. These have their own features, styles, programming interfaces (APIs). This is great but it also means that researchers need to learn each of these individually to use them. It also means that tools and models developed for one don’t necessarily work for others and need to be manually converted. This is often a non-trivial task and limits model reuse. 3/x

"Our study demonstrates a unique role for MANF in autophagy and lysosome function, critical processes for clearing toxic proteins. In the animal model Caenorhabditis elegans, overexpressing MANF extended lifespan, reduced protein clumps, and conferred protection on neurons. These roles of MANF are mediated by the HLH-30/TFEB, a master regulator of lysosome function"

pnas.org/doi/10.1073/pnas.2403