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#metabolite

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When individual deletion #yeast strains cannot grow alone, some can be rescued by neighbouring strains producing a critical #metabolite. A search for cross-complementation by co-culture of mutants identified interesting links between, mostly, aminoacid synthesis pathways.

Some of the genetic interaction remain mysterious, such as those involving the deletion of #ribosomal protein genes RPS24B or RPL27A.

pubmed.ncbi.nlm.nih.gov/372484

PubMedSpontaneously established syntrophic yeast communities improve bioproduction - PubMedNutritional codependence (syntrophy) has underexplored potential to improve biotechnological processes by using cooperating cell types. So far, design of yeast syntrophic communities has required extensive genetic manipulation, as the co-inoculation of most eukaryotic microbial auxotrophs does not r …