datum (n=1)<p>This paper <a href="https://www.nature.com/articles/s42255-025-01290-1" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s42255-025</span><span class="invisible">-01290-1</span></a> is interesting. They tested Vitamin B3 in a pill that is</p><blockquote><p>designed to release nicotinamide [a form of Vitamin B3] in the lower small intestine and colon</p></blockquote><p>And found:</p><p>1️⃣ Acute COVID-19 might be safely and easily reduced in severity and duration<br>2️⃣ In general, no improvement in Long COVID rates (here termed Post-COVID syndrome, PCS)<br>3️⃣ BUT, for people with recovery-like trajectories, they found superior outcomes. This takes a few quotes:</p><p>The subgroup was</p><blockquote><p>participants at risk who had shown improvement in the primary endpoint or one of the three key secondary endpoints in the acute phase of the disease</p><p>In [this] subgroup, a significant benefit of nicotinamide was also observed in participants with PCS (nicotinamide: n = 48, PCS score 8.33 ± 0.84; placebo: n = 57, PCS score 11.82 ± 1.03; absolute difference: −3.49; 95% confidence interval, −6.1 to −0.86; P = 0.010</p></blockquote><p>Now we all know how Long COVID isn't one single disease. Let's assume for a second that other results that suggest at least <em>one</em> subset has a microbiome component are correct.</p><p>As they say "life finds a way" so it would make sense that remnant gut populations could rebound over time and that this subset of LC sufferers might be more likely to have recovery trajectories. (This while we have no treatments for any subset.)</p><p>This obviously won't stop the pandemic nor its consequences, but still, here's hoping that there's no patent encumbrance on coating B3 for lower-gut delivery.</p><p>Of course here in BC we'll get access the same time we get access to Metformin. ⌛ </p><p>h/t <a href="https://zeroes.ca/explore" translate="no" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://</span><span class="">zeroes.ca/explore</span><span class="invisible"></span></a> I think?</p><p><a href="https://zeroes.ca/tags/COVID" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>COVID</span></a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>COVID19</span></a> <a href="https://zeroes.ca/tags/SARS2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SARS2</span></a> <a href="https://zeroes.ca/tags/LongCOVID" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>LongCOVID</span></a> <a href="https://zeroes.ca/tags/PCS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>PCS</span></a> <a href="https://zeroes.ca/tags/B3" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>B3</span></a> <a href="https://zeroes.ca/tags/VitaminB3" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>VitaminB3</span></a> <a href="https://zeroes.ca/tags/AirborneAware" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AirborneAware</span></a> <a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CovidCompetent</span></a></p>